CLK inhibitor T3 ( T3 )

Catalog No. M13352 CAS No. 2109805-56-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

CLK inhibitor T3
Note

Research use only, not for human use.
Brief Description

CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110nM for CLK1,2 and 3, respectively.
Description

CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110nM for CLK1,2 and 3, respectively; displays 200-300-fold selectivity over other dual specificity kinases such as DYRK1A and DYRK1B; induces dose-dependent reduction in exon recognition and exhibits an overlapping, but greater effect on transcriptome splicing compared to KH-CB19.
Synonyms

T3
Pathway

Cell Cycle/DNA Damage
Target

CLK
Recptor

CLK
Research Area

Cancer
Indication

——

CAS Number

2109805-56-1
Formula Weight

482.59
Molecular Formula

C28H30N6O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC1=CN2C=C(C3=CC=NC=C3)C=CC2=N1)C4=CC=C(C(C)(C)C(N5CCN(C)CC5)=O)C=C4
Chemical Name

4-(2-methyl-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)-N-(6-(pyridin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide

1. Funnell T, et al. Nat Commun. 2017 Feb 23;8(1):7.

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